Molecular Details
DICL_CP_0340507
- 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide
Basic Molecular Information
Basic Information
DICL ID
DICL_CP_0340507
PubChem CID
Molecular Formula
C16H20N2O2S2 Molecular Weight
336.482 g/mol
Synonyms/Alias
[MK6-83; 1062271-24-2; 5-methyl-N-(2-(piperidin-1-yl)phenyl)thiophene-2-sulfonamide; RE9JUR6NT4; 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide; 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thi...
InChI Key
IRGYSXZCDAWOOC-UHFFFAOYSA-N
InChI
InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,1...
IUPAC Name
5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide
CAS Number
1062271-24-2
Structure Information
Chemical Structure Visualization
SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF
42 44 0 0 0 0 0 0 0 0999 V2000
4.1115 -4.0147 -0.4066 C 0 0 0 0 0 0 0 0 0 0 0 0
3.5428 -2.6766 -0.7398 C 0 0 0 0 0 0 0 0 0 0 0 0
2.4799 -2.441...
Experimental Data
Activity Data
Target Ion Channel
Transient receptor potential channel mucolipin 1 F465L
Uniprot Accession Number
Function
Activator
Species
Homo sapiens (Human)
IC50
N/A (Not available)
EC50
EC50: 100 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)
Experimental Conditions
pH
pH 7.4
Holding Potential
−200 to 100 mV mV
Temperature
Room Temperature
Test Method
Patch-clamping
Test Species
HEK293 cell (Homo sapiens embryonic kidney 293 cell)
Binding Information
Binding Site
Extracellular domain
Binding Site Residue
F408Δ, F465L
Disease Information
Related Disease
Not specified
References
Computed Properties
Heavy Atom Count
22
Rotatable Bonds
4
logP
3.8476
Complexity
92.3705
TPSA (Ų)
49.41
H-Bond Donors
1
H-Bond Acceptors
4
Ring Count
3